主权项 |
1. A compound of formula (Ia)or a pharmaceutically acceptable salt thereof, wherein:
L1 is
a) C3-C7alkylene, C3-C7alkenylene, or C3-C7alkynylene, wherein the C3-C7alkylene, C3-C7alkenylene, or C3-C7alkynylene are each optionally substituted with 1, 2, 3, or 4 fluoro substituents;b) —(CH2)t-G-(CH2)p—; wherein t is 0, 1, or 2, p is 0, 1, 2, or 3, and t+p=0, 1, 2, 3, or 4; orc) —(CH2)n-G1-(CH2)p—, —(CH2)n-G2-(CH2)p—, —(CH2)n—C≡C-G2-, or —(CH2)n—C(R13)═C(R13)-G2-, wherein n is 1, 2, 3, 4, or 5, p is 0, 1, 2, or 3, and n+p=1, 2, 3, 4, 5, or 6; G is G1 is O, C(O), S, S(O), S(O)2, or NR8; wherein R8 is H, C1-C4 alkyl, or C1-C4alkylcarbonyl; G2 iswherein G2 is optionally substituted with 1, 2, or 3 substituents selected from the group consisting of C1-C4alkyl, C1-C3haloalkyl, cyano, halogen, C1-C3alkoxy, and C1-C3haloalkoxy;
R1 is COOR10, CONR10R11, CH2OR10, SO3R10, SO2NR10R11, PO(OR10)2, or tetrazol-5-yl; R10 is H, C1-C4 alkyl, or aryl; R11 is H, C1-C4 alkyl, COR12, OR10, or SO2R12; R12 is C1-C4 alkyl; R13, at each occurrence, is independently H or C1-C4alkyl; L4 is —C(R2)2—C(R3)2—, —C(R2)═C(R3)—, —C≡C—, orwherein R2 and R3 are each H, CH3, fluoro, or choro;
L2 is a bond; R4 and R5 are each independently H, F, CF3, or C1-C4 alkyl; or R4 and R5 together with the carbon to which they are attached form a C3-C5 cycloalkyl, R6 is C3-C10alkyl; and s is 1. |