| 摘要 |
PURPOSE:To obtain the titled preparation wherein a drug is uniformly dispersed in a pressure-sensitive adhesive agent layer at >=saturated solubility, by adding a solution of a drug in a good solvent for the drug to a solution of a polymer in a poor solvent for the drug, removing a specific amount of the good solvent, applying the prepared dispersion of drug fine particles to a substrate and drying. CONSTITUTION:A solution of a drug in a good solvent (e.g. THF, acetone or methanol) is added to a solution of a polymer in a poor solvent (e.g. n-hexane or toluene) for the drug, having a higher boiling point than the good solvent to give a solution of the drug. The good solvent for the drug is removed (e.g. distilled away under reduced pressure by vacuum emulsifying blender) is removed from the solution of the drug until drug crystal is precipitated to give a dispersion wherein drug fine particles having <=30mum, especially <=15mum average particle diameter are uniformly dispersed, the dispersion is applied to a substrate and dried. The kinds of the solvents, drug concentration and the blending ratio of the drug solution and the polymer solution are determined in such ranges as to precipitate drug crystallite in a state of partial removal of the good solvent and not to form reprecipitation of the polymer.
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