发明名称 |
Preparation process of (6R)-tetrahydro-L-biopterin |
摘要 |
(6R)-Tetrahydro-L-biopterin of the following formula: <IMAGE> is prepared by catalytically reducing L-erythrobiopterin or an acyl derivative thereof in the presence of an amine, at pH 10-13 and with a platinum-base catalyst and when one or more acyl groups still remain, then removing the acyl groups. (6R)-Tetrahydro-L-biopterin is effective for the treatment of certain serious neuroses and malignant hyperphenylalaniemia. The present invention has succeeded in preparing (6R)-tetrahydro-L-biopterin at a high asymmetric ration R/S and moreover with a high yield. Since the process of this invention makes use of an amine as a base, the process is free from admixture of any inorganic salt and can hence provide high-purity crystals with ease.
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申请公布号 |
US4713454(A) |
申请公布日期 |
1987.12.15 |
申请号 |
US19860824288 |
申请日期 |
1986.01.23 |
申请人 |
SHIRATORI PHARMACEUTICAL CO., LTD.;SUNTORY LIMITED |
发明人 |
SAKAI, HIDEAKI;KANAI, TADASHI |
分类号 |
C07D475/04;(IPC1-7):C07D475/04 |
主分类号 |
C07D475/04 |
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