| 摘要 |
PURPOSE:To obtain a platinum complex useful as a carcinostatic agent in a short time in high efficiency, by reacting aminomethylpyrrolidine to a reaction liquid of K2PtCl4 and KSCN and reacting the reaction product with cyclobutanedicarboxylic acid silver salt under a specific condition. CONSTITUTION:Platinum(II) potassium chloride is made to react with potassium thiocyanate preferably at 20-80 deg.C usually for 0.5-5hr. 2-Aminomethylpyrrolidine or its optically active isomer is added to the reaction liquid and reacted usually at 0-100 deg.C for 0.5-10hr to obtain cis-dithiocyanato(2-aminomethylpyrrolidine) platinum(II) of formula I or its optically active isomer. The compound is suspended in water and the suspension is added with silver salt of 1,1- cyclobutanedicarboxylic acid and reacted at 0-100 deg.C usually for 0.5-10hr to obtain the objective compound of formula II or its optically active isomer.
|
