COMPOSITION COMPRISING EPA AND DHA ETHYLESTER FOR PARENTERAL ADMINISTRATION

摘要

Described herein are compositions for parenteral administration that include an aqueous phase and 5 to 30%, by weight, of an oil phase, based on the total weight of the composition. The oil phase comprises the omega-3 fatty acid ethylesters eicosapentaenoic acid ethylester, docosahexaenoic acid ethylester, and mixtures thereof. The composition further comprises at least one anionic surfactant and at least one amphoteric surfactant, and less than 0.05% by weight of oleic acid, based on the total weight of the composition. Also described is a method for preparing such a composition as well as such compositions for use as a medicament, in particular for use in treating stroke, sepsis, Alzheimer's disease or cancer. Also featured are methods of treating these conditions by parenterally administering a composition to a patient in need thereof and methods of providing parenteral nutrition to such patients by administering to them a composition as described herein.

主权项

1. A composition comprising
an aqueous phase and 5 to 30% by weight of an oil phase, based on the total weight of the composition, wherein the oil phase comprises eicosapentaenoic acid ethylester, docosahexaenoic acid ethylester or mixtures thereof and less than 1% by weight medium chain triglycerides, based on the total weight of the composition; an anionic surfactant; and an amphoteric surfactant, wherein the composition is formulated for parenteral administration and comprises less than 0.05% by weight of oleic acid, based on the total weight of the composition.