Cephalosporin compounds, process for their preparation and pharmaceutical compositions containing them.

摘要

Cephalosporin compounds having a 3-position substituent of the formula (I) are described: -CH2-Y-Q (I) wherein Y is a linking group -NR<4>CO-Y'-, -NR<4>SO2-Y'-, -OCO-Y;- or -SCO-Y'- wherein R<4> is hydrogen, various optionally substituted alkyl groups or alkenyl and Y' is a bond or various optionally substituted alkylene or alkenylene groups; and Q is a benzene ring (optionally fused to a further benzene ring so forming a naphthyl group or optionally fused to a 5 or 6 membered heterocyclic aromatic group containing 1, 2 or 3 heteroatoms selected from nitrogen, oxygen and sulphur), said benzene ring (or in the case of naphthyl either benzene ring) being substituted by groups R<1> and R<2> which are ortho with respect to one another, wherein R<1> is hydroxy or an in vivo hydrolysable ester thereof and R<2> is hydroxy, an in vivo hydrolysable ester thereof, carboxy, sulpho, hydroxymethyl, methanesulphonamido or ureido; or Q is a group of the formula (II) or (III): <CHEM> wherein M is oxygen or a group NR<3> wherein R<3> is hydrogen or C1-4 alkyl; ring Q being further optionally substituted. The use of such compounds as antibacterial agents is described as are processes for their preparation and intermediates therefor.