Nanodiamond particle and method of manufacturing the same, and fluorescent molecular probe and method of analyzing structure of protein

摘要

A nanodiamond particle including an NV center having ODMR intensity enhanced, of which surface is modified with a functional group containing a heteroatom, is provided. This nanodiamond particle as being chemically modified can serve for a fluorescent molecular probe which can be made use of in a biological system. By tracking a rotational motion of the NV center included in this fluorescent molecular probe, structural change of a protein can be analyzed in real time. The functional group containing a heteroatom can be at least any functional group of a hydroxyl group and a hydroxyalkyl group, or a carboxyl group.

主权项

1. A nanodiamond particle including a nitrogen atom and a vacancy (NV) center having optically-detected magnetic resonance (ODMR) intensity enhanced, of which surface is modified with an electron-donating functional group, wherein
said ODMR intensity represents a rate of decrease in an amount of fluorescence emission originating from excitation light when a high-frequency magnetic field from 1 to 5 GHz is applied, and said rate of decrease in said amount of fluorescence emission is not less than 0.01.