Cinnamoyl piperidines and thiomorpholine and cerebral protection compositions

摘要

Compounds of the general formula <IMAGE> (I) wherein: X is halogen or trifluoromethyl; R1 is hydrogen, halogen or trifluoromethyl; R2 is hydrogen, methyl or hydroxymethyl; R3 is hydrogen or lower alkyl; and Y is methylene, methylene substituted with a lower alkyl or hydroxyl group, sulfinyl, sulfonyl, oxygen or sulfur, exhibit a cerebral protective effect and are applicable to the treatment of cerebral ischaemia and cerebral hypoxia. The compounds may be made by acylating a suitable piperidine or morpholine with the appropriate cinnamoyl chloride, and if necessary oxidizing the reaction product.