发明名称 |
METHOD FOR DETERMINING VON WILLEBRAND FACTOR ACTIVITY IN THE ABSENCE OF RISTOCETIN AND FOR DETERMINING THE ADAMTS-13 PROTEASE |
摘要 |
The invention is located in the field of coagulation diagnosis and relates to an in vitro method for determining von Willebrand factor (VWF) activity in a sample. The method includes the use of a mutant gain-of-function variant of the GPIb.alpha. protein, thus making it possible to dispense with the use of ristocetin, botrocetin or another ristocetin- or botrocetin-equivalent substance. The invention further relates to a method for determining von Willebrand factor (VWF)-cleaving activity of the ADAMTS-13 protease. |
申请公布号 |
CA2692576(C) |
申请公布日期 |
2016.11.01 |
申请号 |
CA20082692576 |
申请日期 |
2008.07.03 |
申请人 |
SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH |
发明人 |
ALTHAUS, HARALD;OBSER, TOBIAS;PATZKE, JUERGEN;SCHNEPPENHEIM, REINHARD |
分类号 |
C12Q1/37;G01N33/50 |
主分类号 |
C12Q1/37 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|