发明名称 |
KAL1 PROTEIN CONTROLLING CELL CYCLE OF HEMATOPOIETIC STEM CELL, AND USE THEREOF |
摘要 |
The present invention relates to a KAl1 protein controlling the cell cycle of a hematopoietic stem cell and a use thereof, and more specifically, a composition comprising a KAl1(CD82) polypeptide or a gene encoding the same for controlling the cell cycle of a hematopoietic stem cell, or a pharmaceutical composition for preventing or treating blood tumors. In the present invention, KAl1(CD82) is expressed only in a hematopoietic stem cell (LT-HSC) which is the uppermost stem cell in the hierarchy of the hematopoietic stem cell, can obtain an LT-HSC with high purity using the KAl1, and thus can inhibit various side effects of hematopoietic stem cell transplantation by transplanting only an LT-HSC with high purity. In addition, KAl1 importantly acts on the quiescence of an LT-HSC, and has resistance against cell damage due to various stresses (5-FU, irradiation) by maintaining the quiescence of the LT-HSC. Thus, it is expected that the cell can be used for making a cell bank and can be used as a blood tumor cell therapy product through cell transplantation. |
申请公布号 |
WO2016178514(A1) |
申请公布日期 |
2016.11.10 |
申请号 |
WO2016KR04707 |
申请日期 |
2016.05.04 |
申请人 |
SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION |
发明人 |
KIM, Hyo-Soo;HUR, Jin;CHOI, Jae Il;KANG, Jin-A;NHAM, Pniel |
分类号 |
A61K38/17;A61K35/28;C07K14/705;C12N5/0789 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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