FUSED PYRAZOLE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR MEDICINAL USE.

摘要

Novel fused pyrazole compounds represented by general formula (I) (wherein X represents =N- or =CH-, R represents H, alkyl, alkoxy or halogen, Y<1> represents alpha , phenyl or phenyl substituted by halogen, alkyl or alkoxy, Y<2> represents beta , -A<2>-B<2>, H, alkyl, substituted alkyl, phenyl or phenyl substituted by a substituent selected from the group consisting of halogen, alkyl and alkoxy, provided that at least one of Y<1> and Y<2> represents alpha or beta , Z<1> and Z<2> each represents -O-, -S- or -NR<3> (wherein R<3> represents H or alkyl), A<1> and A<2> each represents alkylene, B<1> and B<2> each represents carboxyl, alkoxycarbonyl or phenylalkoxycarbonyl wherein the phenyl group may optionally be substituted by a substituent selected from the group consisting of halogen, alkyl and alkoxy, acyl, -OH, acyloxy, gamma or lambda (wherein R<1> and R<2> represents H, alkyl, dialkylaminoalkyl, hydroxyalkyl or, when taken together, R<1> and R<2> represent a group forming a heterocyclic ring together with the adjacent nitrogen atom), and L<1> and L<2> each represents halogen, alkyl or alkoxy) and salts thereof, a process for their preparation and a medicinal composition containing same are disclosed. The compounds have the action of increasing phagocytosis of leucocytes, that of increasing phagocytosis of macrophage, that of restoring the number of leucocytes, that of activating infection protective function, that of improving immunological competence, an antitumor action, etc. ABSTRACT Novel fused pyrazole compounds of the general formula wherein all the symbols are as defined in the specification or its pharmaceutically acceptable salt which possesses a stimulating action on phagocytosis of leukocytes, a stimulating action on phagocytosis of macrophages, a restorative action on leukopenia, a stimulating action on non-specific resistance to infection, an antitumour action, an activating action on immune responses and the like, and therefore is of use as a pharmaceutical.