发明名称 Trk-inhibiting compound
摘要 The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I), wherein all symbols represent the same meanings as described in the specification, a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.;
申请公布号 US9498453(B2) 申请公布日期 2016.11.22
申请号 US201615173161 申请日期 2016.06.03
申请人 ONO PHARMACEUTICAL CO., LTD. 发明人 Takeuchi Jun;Itadani Satoshi;Hashimura Kazuya;Ikura Masahiro;Higashino Masato;Yasuhiro Tetsuya;Nagaura Takeshi
分类号 A61K31/136;A61K31/444;A61K31/506;A61K31/519;A61K31/663;A61K31/5377;C07D213/75;C07D401/12;C07D401/14;C07D239/47;C07D471/04;C07D487/04;C07D405/14;C07D409/14;A61K45/06 主分类号 A61K31/136
代理机构 Foley & Lardner LLP 代理人 Foley & Lardner LLP
主权项 1. The compound of 1-(2-(4-(2-amino-5-fluoropyridin-3-yl)phenoxy)pyrimidin-5-yl)-3-(2-(pyridin-3-yl)-5-(trifluoromethyl)phenyl)urea or a salt thereof.
地址 Osaka-Shi JP