Aromatic steroid 5-alpha-reductase inhibitors.

摘要

Compounds of formula (I) <CHEM> in which X<1>, X<2> and X<3> are hydrogen, halogen, CF3, C1-6alkyl, OH, C1-6alkoxy, CN, NO2, N(R<1>)2, CHO or CO2R<1>; A is O or S, n is 0 or 1, R<1> is H or C1-8alkyl and R<3> is alpha -H, alpha -OH, or alpha -acetoxy and beta =WCOR<4>, beta -alkOR<8>; or =CHWCOR<4> or =CHWOR<8>; furanyl or alpha -H and beta -NHCOR<9>, beta -cyano or beta -tetrazolyl; or keto; processes for their preparation, intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy as inhibitors of steroid 5- alpha -reductase activity.