发明名称 |
NEW LYSOSPHINGOLIPID DERIVITIVES |
摘要 |
Novel derivatives of lysophingolipids free from sialic acids which are N-acyllysosphingolipids having one of the two formulae: <IMG> (I) (II) in which -A- stands for the group -CH=CH- or -CH2-CH2-, n1 is a whole number of between 6 and 18, n2 a whole number of between 11 and 15, X is a hydrogen atom or the residue of a monosaccharide or a disaccharide or phosphorylcholine and R represents an alkyl radical derived from a saturated or unsaturated aliphatic carboxylic acid having from 2 to 24 carbon atoms substituted by one or more polar groups. The lysosphingolipid derivatives of the invention exhibit an inhibiting action on protein-kinase C activation and, thus, can be utilized in therapies for various pathologies of the nervous system.
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申请公布号 |
CA2004190(A1) |
申请公布日期 |
1990.06.02 |
申请号 |
CA19892004190 |
申请日期 |
1989.11.29 |
申请人 |
FIDIA S.P.A. |
发明人 |
DELLA VALLE, FRANCESCO;ROMEO, AURELIO |
分类号 |
A61K31/16;A61K31/275;A61K31/685;A61K31/70;A61K31/7028;A61P25/00;A61P25/28;C07C215/24;C07C233/18;C07C233/20;C07C235/08;C07C237/22;C07C255/19;C07C323/58;C07F9/10;C07H15/04;C07H15/10;(IPC1-7):C07C233/17;C07C237/04 |
主分类号 |
A61K31/16 |
代理机构 |
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