PROCESS FOR THE PREPARATION OF 3-EXO-METHYLENE-CEPHAM-SULFOXIDE DERIVATIVES AND 2-CHLOROSULFINYL-AZETIDIN-4-ONES

摘要

3 -Exomethylenecepham sulfoxide derivatives and intermediates therefor, viz. 2-chlorosulfinylazetidin-4-ones are prepared in high yield and purity by reaction of a penam sulfoxide ester with a N-chloro halogenating agent in the presence of molecular sieves.