| 摘要 |
<p>There are disclosed compounds of formula I: Q - T - M - G - W - X - J - P - Z I wherein Q represents H-Asp, H- beta Asp, H-DAsp, For, Suc or R<1>R<2>CHOCO, T represents Tyr(SO3H), M represents Ile, G represents Gly, D-Ala or Pro, W represents Trp, X represents Ahx, J represents Asp, P represents MePhe, Z represents NR<3>R<4>, R<1>, R<2>, R<3> and R<4> are independently H or lower alkyl, in addition a) Q and T may together represent Hpp(SO3H), b) when Q represents H- beta Asp, X may represent Ile, c) when G represents D-Ala, M and X may both represent Met d) when Q represents H-DAsp, then M and X may both represent Ile provided that P represents Phe, e) when Q represents H-Asp and G represents Pro, M and X may both represent Met. and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment of obesity.</p> |
