| 摘要 |
11992/22002/11 COMPOUNDS Compounds of structure (I) in which R1 is hydroxy, hydroxyC1-4alkyl, hydroxyC1-4alkoxy, carboxyC1-4alkoxy, C1-4alkoxyC1-4alkoxy, O(CH2)mHet, C1-4alkylNR6R7 or O(CH2)mNR6R7 in which m is 2 to 4 and R6 and R7 are the same or different and are each hydrogen, C1-4alkyl, Het, or -(CH2)nAr where n is 0 to 4, Ar is an optionally substituted phenyl ring, m is 2 to 4 and Het is an optionally substituted heterocyclic ring, or R6 and R7 together with the nitrogen to which they are attached form a saturated or unsaturated ring optionally containing one or more further heteroatoms; R2 and R3 and R4 and R5 are the same, or different and are each hydrogen, C1-4alkyl, -(CH2)nAr in which n is 0 to 4 and Ar is an optionally substituted phenyl ring, or R2 and R3 together with the nitrogen atom to which they are attached form a saturated or unsaturated ring optionally containing one or more further heteroatoms process for their preparation, pharmaceutical compositions containing them and their use in therapy as inhibitors of gastric acid secretion.
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