Substituted triazole boronic acid compounds

摘要

The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are LMP7 inhibitors and may be useful in treating associated inflammatory diseases and disorders such as, for example, rheumatoid arthritis, lupus and irritable bowel disease.;

主权项

1. A compound of formula (I): wherein: R1, R1′ and R1″, of each other, are hydrogen, alkoxy, halogen or —CF3; and R2 is C1-7 alkyl or phenyl, or a pharmaceutically acceptable salt thereof.