Crystal of 6,7-unsaturated-7-carbamoyl morphinan derivative and method for producing the same

摘要

Stable crystalline forms of a compound represented by the formula (IA):;
an acid addition salt, and/or a solvate thereof are provided by the present invention. Said crystalline forms are extremely useful as materials for preparing medicines. Novel processes for preparing 6,7-unsaturated-7-carbamoyl morphinan derivatives are also provided by the present invention.

主权项

1. A process for preparing a compound of the formula (I):wherein R2 is optionally substituted lower alkyl, and R3 is optionally substituted lower alkyl, optionally substituted cycloalkyl, substituted or non-substituted aryl or substituted or non-substituted heteroaryl,characterized by treating with a base a compound of the formula (IIA):wherein R2 and R3 are the same as defined above.