发明名称 Indole-carboxamides
摘要 The present invention relates to compounds of general formula; wherein R1, R2, R3, R4, R5 and R6 are as defined herein are useful for the treat of neurological and neuropsychiatric conditions.
申请公布号 US9464049(B2) 申请公布日期 2016.10.11
申请号 US201615066154 申请日期 2016.03.10
申请人 Hoffmann-La Roche Inc. 发明人 Jagasia Ravi;Jakob-Roetne Roland;Peters Jens-Uwe;Wichmann Juergen
分类号 C07D209/42;C07D209/30;A61K31/4045;C07D401/04 主分类号 C07D209/42
代理机构 代理人
主权项 1. A compound of formula I wherein R1 is aryl or heteroaryl, which are optionally substituted by one, two or three substituents, selected from lower alkyl, halogen, lower alkyl substituted by halogen, hydroxyl, lower alkoxy, lower alkoxy substituted by halogen, cyano or nitro; R2 is halogen, lower alkyl or cyano; R3 is hydrogen or lower alkyl; R4 is hydrogen or lower alkyl; R5, R6 are independently hydrogen or lower alkyl, or R5 and R6 together with the N-atom to which they are attached form a heterocycloalkyl ring; or a pharmaceutically acceptable acid addition salt, a racemic mixture or its corresponding enantiomer and/or optical isomers thereof.
地址 Little Falls NJ US