MOUSE MONOCLONAL ANTIBODIES FOR POST-EXPOSURE TREATMENT OF RABIES

摘要

MOUSE MONOCLONAL ANTIBODIES FOR POST-EXPOSURE TREATMENT OF RABIES A monoclonal antibody cocktail is useful for post-exposure treatment of mammals for rabies and rabies-related viruses. The cocktail is immunoreactive with both glycoprotein and nucleoprotein epitopes of rabies virus and is cross-reactive with rabies-related virus Duvenhage and Mokola. The specific virus neutralizing activity is higher than human or equine anti-rabies hyper-immune sera presently recommended by the World Health Organization as the post-exposure therapy of choice.