发明名称 |
Systems and methods for biomimetic fluid processing |
摘要 |
Systems and methods generating physiologic models that can produce functional biological substances are provided. In some aspects, a system includes a substrate and a first and second channel formed therein. The channels extend longitudinally and are substantially parallel to each other. A series of apertures extend between the first channel and second channel to create a fluid communication path passing through columns separating the channels that extends further along the longitudinal dimension than other dimensions. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate, wherein the first channel flow rate and the second channel flow rate create a differential configured to generate physiological shear rates within a predetermined range in the channels. |
申请公布号 |
AU2015241133(A1) |
申请公布日期 |
2016.10.13 |
申请号 |
AU20150241133 |
申请日期 |
2015.03.30 |
申请人 |
Brigham and Women's Hospital, Inc. |
发明人 |
Thon, Jonathan N.;Italiano, Joseph E.;Mazutis, Linas;Weitz, David A. |
分类号 |
C12M1/00;B01L3/00;C12M3/08 |
主分类号 |
C12M1/00 |
代理机构 |
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代理人 |
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地址 |
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