发明名称 |
NITROSOTHIOL DERIVATIVES, THEIR PRODUCTION AND USE |
摘要 |
Novel nitrosothiol derivatives of the formula: wherein R1 and R2 are independently a hydrogen atom or a hydrocarbon residue which may be substituted; R3 is a hydrogen atom, an acyl group or a hydrocarbon residue which may be substituted; X1 is a hydrogen atom, an acyl group, a lower alkoxy group or a hydrocarbon residue which may be substituted; X2 is an acyl group or a carboxyl group which may be esterified or which may form an amide; with proviso that when X2 is a carboxyl group X1 is not a hydrogen atom or acetyl group and that when both R1 and R2 are hydrogen atoms X is not acetyl group or .gamma.-glutamyl group, and salts thereof, show excellent hypotensive action, antiarrhythmic action, anti-anginal action, cardiotonic action or coronary vasodilation, thus being useful as therapeutic or prophylactic agents for the cardiovascular diseases such as hypertension and anqina pectoris.
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申请公布号 |
CA2022685(A1) |
申请公布日期 |
1991.02.08 |
申请号 |
CA19902022685 |
申请日期 |
1990.08.03 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
GOTO, GIICHI;OHKAWA, SHIGENORI;FUKUMOTO, SHOJI |
分类号 |
A61K38/00;C07C381/00;C07K5/02;C07K5/06;C07K5/062;C07K5/093;(IPC1-7):C07K5/04;A61K38/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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