| 摘要 |
A method of controlling hyperlipidemia in mammals which comprises adminstering to a mammal an amount effective to control hyperlipidemia of a compound having hypolipidemic activity and the structural formula: <IMAGE> wherein R1 and R2, which may be the same or different provided both are not hydrogen when R3 is an alkenyl or cycloalkenyl group, are selected from the group consisting of hydrogen; alkyl of 1 to 18 carbons; substituted alkyl of 1 to 18 carbons; cycloalkyl of 4 to 10 ring carbon atoms; substituted cycloalky of 4 to 10 ring carbon stoms; alkoxy of 1 to 8 carbon atoms; amido; carbamoyl; acyloxy; alkoxycarbonyl; halogen, aryl and substituted aryl, or together R1 and R2 from a C3 to C7 alkylene group; and R3 is hydrogen; lower alkyl; substituted lower alkyl; cycloalkyl; substituted cyloalkyl; aryl; substituted aryl; a group -COR4 were R4 is hydrogen, lower alkyl, substituted lower alkyl, cycloalkyl, substituted cycloalkyl, aryl, or substituted aryl; a group -CONHR5 where R5 has the same meaning as R4; an alkoxycarbonyl group -CO2R6 where R6 has the same meaning as R4; an alkenyl group -CR7=CR8R9 where R7, R8 and R9, which may be the same or different, have the same meaning as R4; a cycloalkenyl group <IMAGE> where n is an integer from 3 to 8; or a group <IMAGE> where R10 and R11 have the same meanings as R4 or together R10 and R11 form a C3 to C7 alkylene group, and R12 and R13, which may be the same or different, have the same meanings as R1 and R2, provided that R1 and R2 are not both hydrogen, the pharmaceutically acceptable salts, and mixtures thereof; and pharmaceutical compositions useful in practicing the method comprising the hypolipidemically active isoxazolidine-3,5-dione compounds and a pharmaceutically acceptable carrier.
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