| 摘要 |
<p>An iontophoresis device comprising a drug reservoir containing the drug in ionic form and in communication with the skin, a skin permeation enhancing agent contained in the reservoir or in a second reservoir also in communication with the skin, an electrode (12) in electrical communication with the drug reservoir, another reservoir containing electrolyte and, optionally, skin permeation enhancing agent and drug in communication with the skin at a location separated from the drug reservoir, an electrode in contact with the electrolyte-containing reservoir, a D.C. power source connected to the electrodes and rate controlling membranes (14) interposed between the reservoirs and the skin that are impermeable to drug in the absence of a voltage difference between the electrodes and permeable to the drug in the presence of a voltage difference. The skin permeation enhancing agent eliminates the skin as a rate-controlling element, thus making the rate of drug administration dependent upon the membrane permeability, which in turn is controlled electrically.</p> |
