<p>A process for the depolymerization and the supersulfation of heparin and the so obtained supersulfated heparins are disclosed. The process comprises treating heparin with oleum containing from 2 to 6% free sulfuric anhydride at a temperature from -10 to +20<o>C. The obtained heparins have molecular weights from 2000 to 5000 and a sulfation degree from 3.4 to 4.3. All of them are endowed with a remarkable antithrombotic activity.</p>
申请公布号
EP0432537(A2)
申请公布日期
1991.06.19
申请号
EP19900122309
申请日期
1990.11.22
申请人
IKETON FARMACEUTICI S.R.L.
发明人
CONTI, RENATO;CASATI, PAOLO;GORINI, MARIA BEATRICE;MAGGI, ANTONIO