发明名称 |
THIAZOLE DERIVATIVES |
摘要 |
2074175 9110656 PCTABS00006 New thiazole derivatives which are a substituted 4- or 5-(.omega.-aminoalkyl)thiazole with formula (1), wherein X represents a nitrogen atom and Y represents a sulphur atom or alternatively X represents a sulphur atom and Y represents a nitrogen atom, n is 1-6, R1 represents a straight or branched alkyl group containing 1-4 carbon atoms and R2 represents an amino group, a process for the preparation of said compounds by ring closure of a 3-bromo-.omega.-phthalimidoalkan-2-one with thiourea under mild conditions, followed by hydrazinolysis or hydrolysis with diluted hydrochloric acid of the resulting phthalimido derivatives and medicaments containing said derivates with formula (1) for the treatment of congestive heart diseases or for the treatment of allergic disorders.
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申请公布号 |
CA2074175(A1) |
申请公布日期 |
1991.07.20 |
申请号 |
CA19912074175 |
申请日期 |
1991.01.18 |
申请人 |
CEDONA PHARMACEUTICALS B.V. |
发明人 |
ERIKS, JOHN C.;STERK, GEERT J.;VAN DER GOOT, HENDERIKUS;TIMMERMANN, HENDRIK |
分类号 |
A61K31/425;A61K31/426;A61K39/39;A61P9/00;A61P37/08;A61P43/00;C07D209/48;C07D277/20;C07D277/28;C07D277/40;C07D277/48;C07D417/06;C07D417/12;(IPC1-7):C07D277/40 |
主分类号 |
A61K31/425 |
代理机构 |
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地址 |
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