| 摘要 |
Novel dithiolane derivatives of formula: <IMAGE> wherein X is, a C2-C7 alkylcarbonyl group, benzoyl group, benzoyl group substituted with 1-3 groups selected from halogen, C1-C4 alkyl, and C1-C4 alkoxy; Y represents C2-C7 alkylcarbonyl group, C2-C7 alkoxycarbonyl group or cyano group; and R represents di (C1-C4 alkylamino) group, morpholino group or piperidino group, are produced by reacting glyoxal sodium bisulfite adduct with amine compounds in the presence of acids and then with dithiolates. The dithiolane derivatives can activate liver functions and are effective for treatment and prophylaxis of hepatitis and other hepatic disorders.
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