| 摘要 |
A process for preparing roxatidine carboxylate hydrochlorate of formula (I) comprises reacting 3-N-[3-[3- 1-piperidinyl)phenoxy propyl hydroxy acetamide with an acid chloride of formula ROCOCl in an inert solvent at 30-100 deg.C for 0.5- 3 hrs. The inert solvent is selected from hexane, benzene, toluene, xylene, ethylether, isopropylether, methylacetate, ethylacetate, methylenechloride, methylacetate, ethylacetate, methylenechloride, chloroform, carbon tetrachloride, dichloroethane or thichloroethane. In the formulas, R= alkyl or aryl. Cpds. (I) are useful as an antiulcer drug.
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