发明名称 |
MONOCLONAL ANTIBODY TO NOVEL ANTIGEN ASSOCIATED WITH HUMAN TUMORS |
摘要 |
PATENT 7190 The present invention is concerned with a novel monoclonal antibody which binds strongly to a protein antigen associated with human tumors, including carcinomas of the colon, breast, and lung, as well as melanomas. The antibody binds to normal human cells to a much lesser degree than to tumor cells. The antibody finds use both in diagnostic methods such as the detection of malignant cells associated with tumors and in therapeutic methods for treatment of humans with tumors. Also disclosed is a novel 70,000 - 75,000 dalton glycoprotein antigen found on the cell surface of human tumor cells. The amino terminal amino acid sequence of this antigen is: in which X represents an unidentified amino acid. 7190APL.1
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申请公布号 |
CA2043951(A1) |
申请公布日期 |
1991.12.06 |
申请号 |
CA19912043951 |
申请日期 |
1991.06.05 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
HELLSTROM, INGEGERD;HELLSTROM, KARL E.;MARQUARDT, HANS;JOHNSTON, JANET |
分类号 |
C12N5/10;A61K38/00;A61K39/00;A61K47/48;A61K51/10;C07K14/47;C07K16/30;C07K16/42;C12N5/20;C12N15/02;C12P21/08;C12R1/91;G01N33/574;G01N33/577;(IPC1-7):C12P21/08;C12N5/18;A61K39/39;A61K39/395 |
主分类号 |
C12N5/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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