| 摘要 |
<p>Ligands that bind to endothelial leukocyte adhesion molecule-1 (ELAM-1) are disclosed. These ligands have the formula (I) wherein each of the saccharide rings shown is connected at its 1-position to the next saccharide at its 3-position or 4-position and wherein at least one of A and B is (II) wherein R4 is -(CHOH)¿3?H, H, alkyl containing 1 to 6 carbons, CHO, or perfluoroalkyl containing 1 to 6 carbons; R?5¿ is H, alkyl containing 1 to 6 carbons, COCH¿3?, COCH2OH or COCF3; R?6¿ is H, or an alkyl containing 1 to 6 carbons; each D is independently H, or a galactosyl or fucosyl residue, wherein at least one D is an α-fucosyl connected to the 3-position or 4-position of the sugar to which it is bound; each R3 is independently selected from the group consisting of OH and NAc; n is an integer of from 0 to 10; and each X is selected from the group consisting of O, S, and NR6 or the X in the sugar at the reducing terminus may represent the corresponding dialcohol at C-1 and C-5.</p> |
