PROCESS FOR THE PREPARATION OF AMINOPYRIMIDINES

摘要

HOE 90/F 274 of the disclosure Process for the preparation of aminopyrimidines 2-Aminopyrimidines of the formula I (I) in which X and Y are O or S and R1 and R2 independently of one another are lower alkyl, alkoxyalkyl or haloalkyl, are obtained by reacting propanediimidates of the formula II R1-X-C(-NH)-CH2-C(=NH)-Y-R2 (II) or salts thereof with cyanamide in the presence of a base at pH values above pH 7. The process allows the aminopyrimidines to be prepared in a one-pot reaction.