发明名称 |
N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors |
摘要 |
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N- hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives. |
申请公布号 |
SI2586435(T1) |
申请公布日期 |
2016.12.30 |
申请号 |
SI20070031845 |
申请日期 |
2007.03.16 |
申请人 |
The Johns Hopkins University;Cardioxyl Pharmaceuticals, Inc. |
发明人 |
Toscano John P.;Cohen Andrew D.;Courtney Stephen Martin;Frost Lisa Marie;Kalish Vincent Jacob;Brookfield Frederick Arthur |
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