发明名称 |
IMMUNOLOGICAL FUNCTION PROMOTING AGENT FOR ORAL AND TRANSCUTANEOUS ADMINISTRATION AND IMMUNOLOGICAL FUNCTION PROMOTING AGENT FOR ANIMAL FOR ORAL AND TRANSCUTANEOUS ADMINISTRATION |
摘要 |
PURPOSE:To provide an immunological function promoting agent for oral and transcutaneous administration, containing Bordetella pertussis LPS, having high immunological function activation capability and high chemotherapeutic index and producible at a low cost. CONSTITUTION:The objective agent contains Bordetella pertussis LPS preferably having a molecular weight of 6000+ or -1000 and 9000+ or -1000 (determined by SDS electrophoresis) and containing 5 P atoms, 16+ or -2 hexosamine groups, 5 fatty acid groups and 2+ or -1 KDO based on 8,000 molecular weight. The immunological function is e.g. macrophage-activation property, especially endogenous TNF- production promoting property. The immunological function promoting activity can be further improved by the combined use of an agent for suppressing the production of prostaglandin (e.g. indomethacin). |
申请公布号 |
JPH04187640(A) |
申请公布日期 |
1992.07.06 |
申请号 |
JP19900315919 |
申请日期 |
1990.11.22 |
申请人 |
CHIBA SEIFUN KK;MIZUNO DENICHI;SOMA GENICHIRO |
发明人 |
SOMA GENICHIRO;YOSHIMURA ATSUSHI;TSUKIOKA DAISUKE;MIZUNO DENICHI;OSHIMA HARUYUKI |
分类号 |
A61K35/74;A61P37/04;A61P43/00 |
主分类号 |
A61K35/74 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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