Bis(benzylpyrrolidine) derivatives useful for treating congestive heart failure and acute renal failure

摘要

Compounds of Formula I <IMAGE> (I) in which: R1 is hydrogen, lower alkyl, -C(O)R3, or -C(O)NR3R4, where R3 and R4 are independently lower alkyl, phenyl, or phenyl lower alkyl; R2 is hydrogen or lower alkyl; and X is -(CH2)m- where m is an integer of 1 to 10, or -(CH2)nY(CH2)n- where n is an integer of 1 to 3 and Y is oxygen or sulfur, their individual R,R-; R,S-; and S,S-stereoisomers, and racemic or non-racemic mixtures of stereoisomers, and their pharmaceutically acceptable salts are dopamine agonist compounds useful in the treatment of hypertension and congestive heart failure in mammals.