| 摘要 |
HOE 91/F045 of the disclosure A process for the preparation of homoserine lactones .alpha.-Amino-.gamma.-butyrolactones (homoserine lactones) are a central structural element in many biologically active compounds. The known syntheses for the preparation of optically active homoserine lactones from D- or L-methio-nine and D- or L-aspartic acid derivatives have disadvantages. Homoserine lactones I and their salts can be prepared enantioselectively according to the invention by catalytic hydrogenation of aldehydes II (I) (II) where R in the formulae is hydrogen, alkyl, alkenyl, alkynyl, it being possible for the aforementioned three radicals to have hetero atoms in the chain, alkylcarbonyl, alkoxycarbonyl, alkylsulfonyl, benzyl, benzyloxycarbonyl, aryloxycarbonyl or arylsulfonyl, it being possible for the four last-mentioned radicals to be optionally substituted in the aryl moiety.
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