METHODS FOR PREPARING ANTI-VIRAL NUCLEOTIDE ANALOGS

摘要

H:/rec/Intrwovn/NRPortbl/DCC/REC/I 13272411.docx-13/09/2016 NqN N N "n{O~ ~NH5 N N/ OH Methods for isolating 9-{(R)-2-[((S)-{ [(S)-1 (isopropoxycarbonyl)ethyl] amino lphenoxyphosphinyl)methoxy]propyl I adenine: (compound 16): a method for preparing, in high diastereomeric purity, intermediate compounds 13 and 15: method for preparing intermediate compound 12: 9-{(R)-2-[((S) I [(S)- 1 -(isopropoxycarbonyl)ethyl] amino lphenoxyphosphinyl)methoxy]propyl I adenine has anti-viral properties.