| 摘要 |
43 Disclosed is a substituted sulfonamide derivative represented by formula (I) or a pharmaceutically acceptable acid addition salt thereof (I) wherein A represents a hydrogen atom or an alkyl group, G represents a methylene group or an alkylene group, Q1 represents an ethylene group, Q2 represents an ethylene group or a trimethylene group, E represents an alkyl group or a group represented by a formula selected from formula (II-a) and (II-b) - G - J - Z (II-a), - G - Z (II-b) wherein G is as defined above, J represents an oxygen atom, a sulfur atom or a nitrogen atom, and Z represents an aryl group unsubstituted or substituted with an alkyl group or an alkoxy group, or a heterocyclic group, an d X represents a quinolyl group, an isoqulnolyl group, a benzothiazolyl group or a quinazolin-4-on group. The substituted sulfonamide derivative and pharmaceutically acceptable acid addition salt thereof affect the bronchial smooth muscle of a mammal, and are useful as an active ingredient of a pharmaceutical composition for the prevention and treatment of respiratory diseases, such as asthma.
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