BENZOPYRANONE, VERFAHREN ZU IHRER HERSTELLUNG UND VERWENDUNG

摘要

Novel 2H-1-benzopyran-2-ones (coumarin derivatives) of general formula (I), and their addition compounds with physiologically tolerable acids, are disclosed. In formula (I): X is an alkylene group having 2-5 C-atoms, or a 2-hydroxypropylene group; Y is a nitrogen atom, a CH group, a COH group, or a carbon atom; R<1> is a phenyl, benzhydryl, benzhydrylidene, benzyl, diphenylhydroxymethyl, pyridinyl or pyrimidinyl residue which is optionally substituted with one or two C1-C5 alkyl groups, one or two halogen atoms, halogen and at the same time C1-C5 alkyl, perfluoralkyl having 1-3 C-atoms, C1-C5 alkoxy, methylendioxy, hydroxy or nitro; R<2> is a straight-chained or branched alkyl group having 1-5 C-atoms, or a cycloalkyl group having 4-6 C-atoms; R<3> is a hydrogen atom, an alkyl group having 1-4 C-atoms, or phenyl; R<4> is a hydrogen atom, an alkyl group having 1-4 C-atoms, a phenyl group or a trifluoromethyl group, or R<3> and R<4> together represent a polymethylene chain -(CH2)n-, in which n is 3 or 4. Methods for manufacturing these compounds, and new intermediate products and methods of manufacture thereof are also disclosed. The novel coumarin derivatives have neuro-protective and anti-allergic properties. Medicaments containing these compounds are also described.