Platinum(II) complexes with thione ligands and methods thereof

摘要

Platinum(II) complexes having thione-based heterocyclic ligands as anticancer agents. The central platinum atom is coordinated by four of the ligands, each having a five-, six- or seven-membered heterocyclic ring with two nitrogen atoms at positions 1 and 3 of the ring and a thiocarbonyl group at position 2. Pharmaceutical compositions incorporated the platinum(II) complexes, methods of synthesizing the complexes and methods of treating cancers with the complexes or pharmaceutical compositions thereof are also described.

主权项

1. A platinum(II) complex of Formula I, Formula II or Formula III:or a pharmaceutically acceptable salt, tautomer, ester, solvate or prodrug thereof; wherein:
R1, R3, R5, R7, R9, R11, R13 and R15 are each independently a hydrogen atom, a halogen atom, an optionally substituted C1-C3 alkyl group, an optionally substituted C1-C3 alkoxy group, an optionally substituted C2-C3 alkenyl group or an optionally substituted C2-C3 alkynyl group when R2, R4, R6, R8, R10, R12, R14 and R16 are each independently a halogen atom, an optionally substituted C1-C3 alkyl group, an optionally substituted C1-C3 alkoxy group, an optionally substituted C2-C3 alkenyl group or an optionally substituted C2-C3 alkynyl group; or R1, R3, R5, R7, R9, R11, R13 and R15 are each independently a halogen atom, an optionally substituted C1-C3 alkyl group, an optionally substituted C1-C3 alkoxy group, an optionally substituted C2-C3 alkenyl group or an optionally substituted C2-C3 alkynyl group when R2, R4, R6, R8, R10, R12, R14 and R16 are each independently a hydrogen atom, a halogen atom, an optionally substituted C1-C3 alkyl group, an optionally substituted C1-C3 alkoxy group, an optionally substituted C2-C3 alkenyl group or an optionally substituted C2-C3 alkynyl group; R17-R24 are each independently a hydrogen atom, a halogen atom, an optionally substituted C1-C3 alkyl group, an optionally substituted C1-C3 alkoxy group, an optionally substituted C2-C3 alkenyl group or an optionally substituted C2-C3 alkynyl group; and R25-R60 are each independently a hydrogen atom, a halogen atom, an optionally substituted C1-C8 alkyl group, an optionally substituted C1-C8 alkoxy group, an optionally substituted C2-C8 alkenyl group or an optionally substituted C2-C8 alkynyl group.