发明名称 |
EPITOPE MAPPING OF THE C33C REGION OF HCV |
摘要 |
2099883 9309253 PCTABS00022 An assay for detection of serum antibodies having specificity to hepatitis C viral antigens utilizes the carboxy-terminal 102 amino acids of the c33c region of nonstructural gene 3 of HCV containing substantially all the epitopes of the gene 3 protein. In the preferred embodiment the recombinant 102 amino acid peptide is coated onto a solid support, and incubated in the presence of serum obtained from a patient infected with HCV. The presence of antibodies bound to the antigen coated support is detected in a sandwich format utilizing a second reporter-conjugated antibody.
|
申请公布号 |
CA2099883(A1) |
申请公布日期 |
1993.05.08 |
申请号 |
CA19922099883 |
申请日期 |
1992.11.04 |
申请人 |
DADE INT INC |
发明人 |
KINK JOHN A;RYAN TERENCE E;TODD JOHN A;SAEED BADR |
分类号 |
C07K14/00;C07K14/02;C07K14/10;C07K14/18;C12N1/21;C12N15/09;C12P21/02;C12P21/08;C12R1/19;G01N33/53;G01N33/576;(IPC1-7):C07K14/18 |
主分类号 |
C07K14/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|