| 摘要 |
FIELD: organic chemistry. SUBSTANCE: product: compounds of the formulaand their pharmaceutically acceptable salts where R- hydrogen atom, alkyl, hydroxyl, carboxyalkylene, alkoxycarbonylalkenyl, hydroxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, alkoxy, halogen-containing alkyl, carboxyl, alkoxycarbonyl or alkanoylamino-group; R- hydrogen atom, halogen atom, alkoxy-, hydroxy-, alkanoyloxy- or phenoxy-group; R- hydrogen atom or alkyl group; R- hydrogen atom, halogen atom, alkoxycarbonyl, benzylcarbonyl, alkanoyl, benzoyl, carbamoyl, alkyl, carboxyl, hydroxyalkyl or alkylthio-group; R- hydrogen atom or alkyl group; R- hydrogen atom, alkyl group (possibly substituted with one or more substituents taken from hydroxy-group, halogen atom or amino-group of the formula NRR), alicyclic hydrocarbon, phenyl, (cycloalkyl)alkyl or benzyl group; R- hydrogen atom, halogen atom, trifluoromethyl, trifluoromethoxy, alkyl, carboxyl or alkoxy-group; R- hydrogen atom, halogen atom, trifluoromethyl, trifluoromethoxy, alkyl or alkoxy-group; R- hydrogen atom or alkyl group. Synthesized compounds are antirheumatic agents. Also, compositions containing these compounds and methods of their synthesis were given. EFFECT: improved method of synthesis. |
