| 发明名称 | Anti-CXCR4 antibody and its use for the detection and diagnosis of cancer | ||
| 摘要 | The present invention provides a novel, isolated anti-CXCR4 antibody for use in the diagnosis of cancer. In particular, the antibody of the invention recognizes monomeric and homodimeric CXCR4, but not heterodimeric CXCR4. | ||
| 申请公布号 | US9518120(B2) | 申请公布日期 | 2016.12.13 |
| 申请号 | US201214235274 | 申请日期 | 2012.07.30 |
| 申请人 | Pierrre Fabre Medicament | 发明人 | Klinguer-Hamour Christine;Jouhanneaud Alexandra;Janin-Bussat Marie-Claire |
| 分类号 | C07K16/28;G01N33/574 | 主分类号 | C07K16/28 |
| 代理机构 | Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P. | 代理人 | Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P. |
| 主权项 | 1. An anti-CXCR4 antibody, or a CXCR4-binding fragment thereof, comprising i) a heavy chain comprising the following three CDRs, respectively CDR-H1 having the sequence SEQ ID No. 1, CDR-H2 having the sequence SEQ ID No. 2, and CDR-H3 having the sequence SEQ ID No. 3; and ii) a light chain comprising the following three CDRs, respectively CDR-L1 having the sequence SEQ ID No. 4, CDR-L2 having the sequence SEQ ID No. 5, and CDR-L3 having the sequence SEQ ID No. 6. | ||
| 地址 | Boulogne-Billancourt FR | ||