N-((2-OXOPYRROLIDIN-1-YL) ACETYL)) PIPERAZINE DERIVATIVES AND DRUG FOR SENILE DEMENTIA

摘要

A compound of the formula : (I) (wherein R is -SO2Ri or -CONHR2; R' is C1-C6 alkyl, C8-C1 2 phenylalkenyl, amino, dimethylamino, optionally substituted C6-C1 2 aryl, or 5- or 6-membered heterocyclic group including at least one hetero atom selected from the group consisting of N, S, and O; R2 is amino, C1-C6 alkylamino, C1-C6 alkyl, or optionally substituted C6-C1 2 aryl)or its pharmaceutically acceptable acid-addition salt, being useful as a drug for senile dementia, psychotropic, or antiamnesia agent is provided through several routes.