发明名称 |
QUINAZOLINES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE |
摘要 |
206/RDM103 18727IA TITLE OF THE INVENTION NEW QUINAZOLINES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE Compounds having a quinazolin-2-one nucleus with a substituted alkynyl or substituted alkenyl at the 4-position are described. These compounds are useful in the inhibition of HIV reverse transcriptase (including its resistant varieties), the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
|
申请公布号 |
CA2095194(A1) |
申请公布日期 |
1993.11.08 |
申请号 |
CA19932095194 |
申请日期 |
1993.04.29 |
申请人 |
MERCK & CO., INC. |
发明人 |
LYLE, TERRY A.;TUCKER, THOMAS J.;WISCOUNT, CATHERINE M. |
分类号 |
A61K31/505;A61K31/517;A61P31/12;C07D239/80;C07D401/06;C07D401/12;C07D403/06;C07D405/12;(IPC1-7):C07D239/80;C07D401/02;C07D453/02;C07D405/06;C07D409/06;C07D413/06;C07D417/06;A61K31/535;A61K31/54;A61K31/55 |
主分类号 |
A61K31/505 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|