发明名称 |
Hydroxamic acid derivatives as collagenase inhibitors. |
摘要 |
<p>The invention provides hydroxamic acid derivatives of the formula <CHEM> wherein R<1> represents a 5- or 6-membered N-heterocyclic ring, R<2> and R<3> each represent lower alkyl or NR<2>R<3> represents a saturated 5-, 6- or 7-membered heterocyclic ring, R<4>, R<5>, R<6> and R<7> each represent hydrogen or methyl, provided that at least two of these symbols represent hydrogen and n stands for 1-4, and their pharmaceutically acceptable salts, which are collagenase inhibitors useful for the control or prevention of degenerative joint diseases such as rheumatoid arthritis and osteoarthritis or for the treatment of invasive tumours, atherosclerosis or multiple sclerosis.</p> |
申请公布号 |
EP0574758(A1) |
申请公布日期 |
1993.12.22 |
申请号 |
EP19930108628 |
申请日期 |
1993.05.28 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
BROADHURST, MICHAEL JOHN;BROWN, PAUL ANTHONY;JOHNSON, WILLIAM HENRY;LAWTON, GEOFFREY |
分类号 |
C07D239/52;C07D239/54;C07D239/88;C07D249/12;C07D253/06;C07D271/06;C07D271/07;C07D295/18;C07D401/06;C07D401/12;C07D403/06;C07D403/12;C07D407/06;C07D413/06;C07D413/12;C07D417/06;C07D417/12;C07D491/10;C07D491/113;C07K5/06;C07K5/10;C12N9/99;A61K31/40;A61K;A61K31/16;A61K31/165;A61K31/395;A61K31/4015;A61K31/403;A61K31/4035;A61K31/404;A61K31/415;A61K31/4166;A61K31/4245;A61K31/425;A61K31/4427;A61K31/445;A61K31/495;A61K31/496;A61K31/50;A61K31/53;A61K31/535;A61K31/536;A61K31/5375;A61K31/5377;A61K31/54;A61K31/55;A61K33/08;A61P9/10;A61P29/00;A61P35/00;A61P43/00;C07C;C07C259/10;C07C317/44;C07C323/04;C07C333/24;C07D;C07D207/26;C07D207/27;C07D207/40;C07D207/404;C07D207/408;C07D209/18;C07D209/48;C07D211/88;C07D233/72;C07D233/74;C07D233/96;(IPC1-7):C07D209/48 |
主分类号 |
C07D239/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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