发明名称 2-Amino-5-heterocyclic-substituted-1,4-benzodiazepines and their use in the treatment of aids.
摘要 <p>The benzodiazepines of formula &lt;CHEM&gt; where X and Y are each independently selected from H, halogen, and lower alkyl; R&lt;1&gt;&lt;0&gt; and R&lt;1&gt;&lt;1&gt; are both H, or one of R&lt;1&gt;&lt;0&gt; and R&lt;1&gt;&lt;1&gt; is H and the other is methyl, or R&lt;1&gt;&lt;0&gt; and R&lt;1&gt;&lt;1&gt; together are -(CH2)n- where n = 4 or 5; Z is a ring selected from the group consisting of &lt;CHEM&gt; where one or more carbon atoms in said ring Z can be substituted by F, Cl or lower alkyl; as well as the pharmaceutically acceptable acid addition salts, carbamates, ureas and amides thereof can be used as therapeutically active agent, especially as antiviral agents, particularly for the treatment, therapy or prophylaxis of AIDS and AIDS-related diseases.</p>
申请公布号 EP0574781(A2) 申请公布日期 1993.12.22
申请号 EP19930109079 申请日期 1993.06.05
申请人 F. HOFFMANN-LA ROCHE AG 发明人 HSU, MING-CHU;HURYN, DONNA MARY;TAM, STEVE YIK-KAI
分类号 A61K31/55;A61P31/12;A61P31/18;C07D207/323;C07D231/12;C07D243/00;C07D243/20;C07D249/04;C07D403/04;C07D403/14;(IPC1-7):C07D403/04 主分类号 A61K31/55
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