NON-PEPTIDIC SURROGATES OF THE LDV SEQUENCE AND THEIR USE IN THE TREATMENT OF INFLAMMATION, AUTOIMMUNE DISEASES AND TUMOUR PROGRESSION

摘要

Non-peptidic Leu-Asp-Val (LDV) surrogates of formula (I), wherein X1 to X5 are the same or different C, N, O or S atoms, at least two of them being C, and the X1-X5 chain may be optionally substituted by radicals selected from halogen, hydrocarbyl, oxo, thioxo, amino and carboxyl, or the X1-X5 chain or part thereof may form part of a heterocyclic ring, and pharmaceutically acceptable salts thereof, inhibit cellular or molecular interactions which depend on recognition of the LDV sequence, and are useful for the treatment of inflammation and disorders involving interference with cell-matrix or cell-cell dependent immune processes, such as autoimmune diseases and allergy, and inhibition of tumour progression and metastasis.