| 摘要 |
The present invention concerns steroidic 5 alpha -reductase inhibitors having formula (I), wherein the symbol - &cir& _- &cir& _- &cir& _- &cir& _ is a single or a double bond; A is a CH group or an N-R group wherein R is a hydrogen atom or a C1-C4 alkyl group provided that, when A is a CH group, (Y) is a double bond, and when A is an N-R group, (Y) is a single bond and in position 5 there is a hydrogen atom with alpha configuration; B is an oxygen atom or a sulphur atom; each of R1, R2, R3 independently is a hydrogen atom or a C1-C6 alkyl group or an aryl group wherein, optionally, one or more hydrogen atoms are substituted by one or more fluorine atoms provided that at least one hydrogen atom in R1, R2, R3 is substituted by a fluorine atom. The compounds of the invention are therapeutically useful in, e.g., benign prostatic hyperplasia, prostatic and breast cancers, seborrhoea, female hirsutism and male pattern baldness. |
