Method of forming a tissue scaffold

摘要

A process of forming a tissue scaffold is described, the process comprising electrospinning polymer fibers from a spinneret onto a tissue scaffold template. In embodiments, the fibers are plasma-treated between the spinneret and the template. The scaffold may be constructed of alternating layers of aligned and randomly oriented fibers. The scaffold may be heat treated to control the mechanical properties of the scaffold, such as density, pore size and pore interconnectivity.

主权项

1. A method of forming a tissue scaffold, the method comprising:
providing an electrospinning apparatus comprising a spinneret, a tissue scaffold template spaced from the spinneret, an anode and a cathode spaced apart from the anode, the anode and the cathode positioned between the spinneret and the template; applying a voltage to each of the anode and the cathode to generate a region of plasma therebetween; and electrospinning a polymer from the spinneret onto the template, by electrospinning the polymer through the region of plasma to expose the polymer to a plasma, to form the tissue scaffold.